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Keep an eye on Intently (one)istradefylline will raise the stage or impact of salmeterol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.fedratinib will increase the amount or impact of salmeterol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Regulate dose of medication that are CYP3A4 substrates a